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A Nonparametric Population Pharmacokinetic Model of Selumetinib in Pediatric Patients Diagnosed With Neurofibromatosis‐I or Plexiform Neurofibromas

ABSTRACT A twice‐daily administration of oral selumetinib (SLT) in the fasted state is the only approved pharmaceutical option for treating inoperable neurofibromatosis type I (NF‐1) and plexiform neurofibromas (PN). In children, exposure to SLT is highly variable, and fasting presents a substantial...

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Principais autores: Zoltán Köllő, Janka Kovács, Michael N. Neely, Barna Vásárhelyi, Edit Brückner, Attila J. Szabo, Miklós Garami, Gellért Balázs Karvaly
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-01-01
Serier:CPT: Pharmacometrics & Systems Pharmacology
Fag:
oncology
personalized medicine
pharmacometrics
population pharmacokinetics
Online adgang:https://doi.org/10.1002/psp4.70156
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