Enhancing tylosin production by combinatorial overexpression of efflux, SAM biosynthesis, and regulatory genes in hyperproducing Streptomyces xinghaiensis strain

Tylosin is a 16-membered macrolide antibiotic widely used in veterinary medicine to control infections caused by Gram-positive pathogens and mycoplasmas. To improve the fermentation titer of tylosin in the hyperproducing Streptomyces xinghaiensis strain TL01, we sequenced its whole genome and identi...

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Bibliografische Detailangaben

Hauptverfasser:	Penghui Dai, Yuyao Qin, Luyuan Li, Haidi Li, Lihuo Lv, Danying Xu, Yuqing Song, Tingting Huang, Shuangjun Lin, Zixin Deng, Meifeng Tao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	KeAi Communications Co., Ltd. 2023-09-01
Schriftenreihe:	Synthetic and Systems Biotechnology
Schlagworte:	Streptomyces xinghaiensis Tylosin Combinational metabolic engineering
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2405805X2300056X
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