Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint
Megakaryocytes are naturally polyploid cells that increase their ploidy by endomitosis. However, very little is known regarding the mechanism by which they escape the tetraploid checkpoint to become polyploid. Recently, it has been shown that the tetraploid checkpoint was regulated by the Hippo-p53...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Ferrata Storti Foundation
2016-12-01
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| coleção: | Haematologica |
| Acesso em linha: | https://haematologica.org/article/view/7903 |
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