Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells

This study shows that Prpf8 mutations associated with human retinal degeneration in mice alter circRNA expression in cerebellar granule cells and induce their apoptosis. A subset of patients with retinitis pigmentosa (RP) carry mutations in several spliceosomal components including the PRPF8 protein...

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Detalles Bibliográficos

Principais autores:	Michaela Krausová, Michaela Kreplová, Poulami Banik, Zuzana Cvačková, Jan Kubovčiak, Martin Modrák, Dagmar Zudová, Jiří Lindovský, Agnieszka Kubik-Zahorodna, Marcela Pálková, Michal Kolář, Jan Procházka, Radislav Sedláček, David Staněk
Formato:	Artigo
Idioma:	Inglês
Publicado:	Life Science Alliance LLC 2023-06-01
Series:	Life Science Alliance
Acceso en liña:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201855
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