Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Abstract Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (HCE) in complex with its neuronal receptor synaptic vesicle glycoprotein...

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Hlavní autoři:	Zheng Liu, Pyung-Gang Lee, Nadja Krez, Kwok-ho Lam, Hao Liu, Adina Przykopanski, Peng Chen, Guorui Yao, Sicai Zhang, Jacqueline M. Tremblay, Kay Perry, Charles B. Shoemaker, Andreas Rummel, Min Dong, Rongsheng Jin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-04-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-023-37860-8
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