The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

Post-translational modifications (PTMs) expand the structural diversity of proteins beyond the standard amino acids, influencing protein-protein interactions. Protein methylation, a prevalent PTM, involves the transfer of methyl groups from S-adenosylmethionine (SAM) to lysine and arginine residues....

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Autors principals:	Tina M. Sawatzky, Sarah A. Mann, Jordan Shauna Tucker, Aida A. Bibart, Corey P. Causey, Bryan Knuckley
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-10-01
Col·lecció:	Biomolecules
Matèries:	PRMT arginine methyltransferase substrate specificity histones post-translational
Accés en línia:	https://www.mdpi.com/2218-273X/15/11/1494
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