The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation

Abstract Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen, we identify RNAseK, a highly conserved transmembra...

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Autors principals:	Agata N. Makar, Alina Boraman, Peter Mosen, Joanne E. Simpson, Jair Marques, Tim Michelberger, Stuart Aitken, Ann P. Wheeler, Dominic Winter, Alex von Kriegsheim, Noor Gammoh
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-09-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-024-52049-3
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