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Pleiotropic influence of DNA methylation QTLs on physiological and ageing traits

DNA methylation is influenced by genetic and non-genetic factors. Here, we chart quantitative trait loci (QTLs) that modulate levels of methylation at highly conserved CpGs using liver methylome data from mouse strains belonging to the BXD family. A regulatory hotspot on chromosome 5 had the highest...

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Principais autores: Khyobeni Mozhui, Hyeonju Kim, Flavia Villani, Amin Haghani, Saunak Sen, Steve Horvath
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2023-12-01
Serier:Epigenetics
Fag:
methylation
epigenome
ageing
metabolism
genetics
lifespan
Online adgang:http://dx.doi.org/10.1080/15592294.2023.2252631
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