Assessment of Angiopep-2 targeting intracerebral α-synuclein aggregates in a PFF-induced rat model of Parkinson’s disease based on 7T CEST-MRI

α-Synuclein has been demonstrated to deposit early in the brains of individuals with Parkinson’s disease (PD). Detecting α-synuclein aggregates can enhance the accuracy of early PD diagnosis. In this study, we investigated the feasibility of the peptide probe Angiopep-2 (ANG) for targeting and visua...

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Главные авторы:	Lingfeng Lai, Beibei Chen, Liang Xu, Mingmin Wu, Runrun Wang, Zerui Zhuang, Geng Dong, Dan Qi, Kai Lin, Dian Li, Yi He, Yan Lin, Shuyi Sun, Xinhui Zheng, Yue Chen, Yanlong Jia, David J. Mikulis, Erxi Wu, Xiaolei Zhang, Teng Zhou, Jitian Guan, Renhua Wu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2026-04-01
Серии:	Brain Research Bulletin
Предметы:	Parkinson’s disease MRI-CEST Angiopep-2 α-synuclein Molecular docking
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S0361923026000699
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