Single-cell transcriptome sequencing reveals the immune microenvironment in bronchoalveolar lavage fluid of checkpoint inhibitor-related pneumonitis

Abstract Background and objectives Immune checkpoint inhibitors (ICIs) bring cancer patients tumor control and survival benefits, yet they also trigger immune-related adverse effects (irAEs), notably checkpoint inhibitor-related pneumonitis (CIP), affecting about 5% of patients among whom 1–2% exper...

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Principais autores:	Linpeng Zheng, Fenglin Lin, Dingqin Cai, Longyao Zhang, Chenrui Yin, Yaxian Qi, Lingyou Sun, Lingchen Li, Xiewan Chen, Jianbo Zhu, Jianguo Sun
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer 2025-03-01
Series:	Cancer Immunology, Immunotherapy
Assuntos:	Checkpoint inhibitor-related pneumonitis Single-cell RNA sequencing Aberrant basaloid cell Neutrophil T cell Macrophage
Acceso en liña:	https://doi.org/10.1007/s00262-025-03983-8
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