Precision immunotherapy with CAR-T cells in pediatric B-cell acute lymphoblastic leukemia: advances and unanswered challenges

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a groundbreaking treatment for pediatric B-cell acute lymphoblastic leukemia (B-ALL), especially for patients with relapsed or refractory disease. CD19-targeted CAR T cells, such as tisagenlecleucel, have demonstrated high rates of comple...

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Detalhes bibliográficos

Principais autores:	Fu Li, Libo Zheng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
Colecção:	Frontiers in Oncology
Assuntos:	CAR-T therapy cytokine release syndrome immune effector cell-associated neurotoxicity syndrome pediatric B-ALL tisagenlecleucel
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1691189/full
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