Monoclonal IgM antibodies mediate potent complement neutralization by targeting cell-derived epitopes on enveloped viruses

ABSTRACT When studying virus neutralization by specific antibodies of the adaptive immune response, serum heat treatment is a standard procedure done to eliminate any non-specific effects by the complement system. Although non-specific, innate immune responses such as these may be relevant in determ...

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Auteurs principaux:	Markus H. Kainulainen, Jessica R. Harmon, Éric Bergeron, Katherine A. Davies, Morgan L. LeBlanc, Cristina Clines, Meghan L. Bentz, Joel M. Montgomery, Christina F. Spiropoulou
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2026-03-01
Collection:	mBio
Sujets:	neutralizing antibodies broadly neutralizing antibodies antibody specificity IgM antibody complement ganglioside
Accès en ligne:	https://journals.asm.org/doi/10.1128/mbio.01709-25
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