Efficacy and safety of ATRA plus arsenic trioxide versus ATRA plus chemotherapy in newly diagnosed acute promyelocytic leukemia: a grade-assessed systematic review and meta-analysis

Abstract Background Acute promyelocytic leukemia (APL) is an aggressive malignancy. Although recent advancements in therapy have improved outcomes, differing toxicity profiles remain. The optimal choice between all-trans retinoic acid plus arsenic trioxide (ATRA + ATO) and ATRA plus chemotherapy, in...

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Principais autores:	Hassan Ahmad, Fathimathul Henna, Sana Khurram, Ayesha Khan, Alisha Ahmed, Muhammad Hasnain Ali, Mohammad Aitzaz Hassan, Muhammad Abbas, Danyal Farooq, Sher Muhammad, Ali Abdul Basit, Ashfaq Ahmad
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-03-01
Series:	BMC Cancer
Assuntos:	Acute promyelocytic leukemia All trans retinoic acid Arsenic trioxide Efficacy Gastrointestinal toxicity
Acceso en liña:	https://doi.org/10.1186/s12885-026-15932-4
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