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LncRNA GAS5 attenuates COPD pathogenesis by stabilizing p120 catenin to suppress NF-κB-driven inflammation

Abstract Objective To investigate the role of lncRNA GAS5 in COPD and its underlying mechanism. Methods COPD mouse model was conducted as an in vivo inflammatory response model. CSE was used to stimulate human airway epithelial cells (16HBE) and human normal lung epithelial cells (BEAS-2B) to establ...

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Principais autores: Chao Zhang, Xiaoqian Zhan, Yue Li, Zhe Zheng, Xiaoyang Ji, Liuye Yang, Xi Wang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-12-01
coleção:Respiratory Research
Assuntos:
COPD
LncRNA GAS5
P120 catenin
NF-κB
Inflammation
Acesso em linha:https://doi.org/10.1186/s12931-025-03445-w
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