Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) is notably resistant to conventional chemotherapy and radiation treatment. However, clinical trials indicate that carbon ion radiotherapy (CIRT) with concurrent gemcitabine is effective for unresectable locally advanced PDAC. This study aimed to ident...

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Detalles Bibliográficos

Principais autores:	Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-01-01
Series:	npj Precision Oncology
Acceso en liña:	https://doi.org/10.1038/s41698-025-00800-4
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