Pichia pastoris-expressed Dengue 3 Envelope-based Virus-like Particles Elicit Predominantly Domain III-Focused High Titer Neutralizing Antibodies

Dengue poses a serious public health risk to nearly half the global population. It causes ~400 million infections annually and is considered to be one of the fastest spreading vector-borne diseases. Four distinct serotypes of dengue viruses (DENV-1, -2, -3 and -4) cause dengue disease, which may be...

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Hlavní autoři:	Lav eTripathi, Shailendra eMani, Rajendra eRaut, Ankur ePoddar, Poornima eTyagi, Upasana eArora, Aravinda ede Silva, S eSwaminathan, Navin eKhanna
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2015-09-01
Edice:	Frontiers in Microbiology
Témata:	Dengue neutralizing antibody Pichia pastoris Dengue vaccine Virus-like particle (VLP) Antibody-dependent enhancement (ADE)
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01005/full
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