Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer

ObjectiveThis study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene (POLE) in endometrial cancer (EC) and to investigate the effects of EDMs on tumor cell behavior and catalytic activities of Polϵ.MethodsPOLE sequencing was performed in tumor tissue samp...

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Bibliografiska uppgifter

Huvudupphov:	Wenjuan Tian, Zhaodong Ji, Jingshu Wang, Jiao Meng, Rui Bi, Yulan Ren, Boer Shan, Gong Yang, Huaying Wang
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2022-10-01
Serie:	Frontiers in Oncology
Ämnen:	endometrial cancer DNA polymerase epsilon 3’-5’-Exonuclease DNA replication hotspot exonuclease domain mutations
Länkar:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1018034/full
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