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Recombinant BCG Expressing the Subunit 1 of Pertussis Toxin Induces Innate Immune Memory and Confers Protection against Non-Related Pathogens

BCG has shown the ability to induce protection against unrelated pathogens, which likely depends on an immune mechanism known as innate immune memory or trained immunity. In this study, we evaluated the induction of innate memory by a recombinant BCG strain expressing the genetically detoxified S1 s...

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Principais autores: Alex I. Kanno, Diana Boraschi, Luciana C. C. Leite, Dunia Rodriguez
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-02-01
Serier:Vaccines
Fag:
BCG
recombinant BCG
rBCG-S1PT
innate immune memory
trained immunity
Online adgang:https://www.mdpi.com/2076-393X/10/2/234
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