CREB–KIF1A–CGRP-positive feedback loop drives central sensitization in chronic migraine

Abstract Background Chronic migraine (CM), defined as ≥ 15 monthly headache days and often involving central sensitization, is a complex neurological disorder. While calcitonin gene-related peptide (CGRP) is a key migraine target, its upstream regulation remains unclear. Kinesin family member 1A (KI...

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Autori principali: Wei Jiang, Peng Yu, Yan-Min Shi, Li-Xi Zhang, Meng-Tan Cai, Yu Yang, Ming Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-09-01
Serie:The Journal of Headache and Pain
Soggetti:
Migraine
Central sensitization
KIF1A
CREB
Positive feedback loop
Accesso online:https://doi.org/10.1186/s10194-025-02147-4
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