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Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome

Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of congenital heart disease; however, its etiology remains largely unknown. We previously demonstrated that genetic variants in the MYH6 gene are significantly associated with HLHS. Additionally, induced pluripotent...

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Автори: Min-Su Kim, Brandon Fleres, Jerrell Lovett, Melissa Anfinson, Sai Suma K. Samudrala, Lauren J. Kelly, Laura E. Teigen, Matthew Cavanaugh, Maribel Marquez, Aron M. Geurts, John W. Lough, Michael E. Mitchell, Robert H. Fitts, Aoy Tomita-Mitchell
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2020-06-01
Серія:Frontiers in Cell and Developmental Biology
Предмети:
HLHS
hypoplastic left heart syndrome
iPSC-cardiomyocytes
MYH6
contractility
CRISPR/Cas9
Онлайн доступ:https://www.frontiersin.org/article/10.3389/fcell.2020.00440/full
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