BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells

Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the largest subunit of the NURF chromatin remodeling complex, is ess...

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Hlavní autoři:	Wesley D. Frey, Anisha Chaudhry, Priscila F. Slepicka, Adam M. Ouellette, Steven E. Kirberger, William C.K. Pomerantz, Gregory J. Hannon, Camila O. dos Santos
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2017-07-01
Edice:	Stem Cell Reports
Témata:	chromatin remodeling gene regulation mammary stem cells enhancer landscape mammary gland development BPTF
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2213671117301856
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