Efficient induction of EPSCs via episomal reprogramming: a functionally equivalent yet transcriptionally specialized alternative to EPSCs

This study establishes a streamlined one-step strategy using optimized episomal plasmid reprogramming to directly generate extended pluripotent stem cells (dEPSCs) from human peripheral blood mononuclear cells (PBMCs), bypassing the induced pluripotent stem cell(iPSCs) intermediary phase and reducin...

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Autori principali:	Ran Zheng, Mengna Zhang, Yanhong Cheng, Junjie Wen, Xiyu Zhao, Dan Xiao, Jingyu Xu, Ke Pei, Liang Wang, Jie Xu, Jian Zhang, Cheguo Cai, Yunfeng Gao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-08-01
Serie:	Stem Cell Research
Soggetti:	Extended pluripotent stem cells Episomal plasmid reprogramming Differentiation Pluripotent analysis Transcriptome analysis
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1873506126001236
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