Mitapivat, a novel pyruvate kinase activator, for the treatment of hereditary hemolytic anemias
Mitapivat (AG-348) is a novel, first-in-class oral small molecule allosteric activator of the pyruvate kinase enzyme. Mitapivat has been shown to significantly upregulate both wild-type and numerous mutant forms of erythrocyte pyruvate kinase (PKR), increasing adenosine triphosphate (ATP) production...
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| Principais autores: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
SAGE Publishing
2021-12-01
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| 叢編: | Therapeutic Advances in Hematology |
| 在線閱讀: | https://doi.org/10.1177/20406207211066070 |
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