Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration

Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to spare glucose. We hypothesized that persistent st...

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Autors principals:	Melissa A. Linden, Susan J. Burke, Humza A. Pirzadah, Tai-Yu Huang, Heidi M. Batdorf, Walid K. Mohammed, Katarina A. Jones, Sujoy Ghosh, Shawn R. Campagna, J. Jason Collier, Robert C. Noland
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-08-01
Col·lecció:	Molecular Metabolism
Matèries:	Glucocorticoid Substrate overload Lipolysis Adipose triglyceride lipase Iatrogenic diabetes
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2212877823000856
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