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Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0

Indoleamine 2,3-dioxygenase (IDO1) is a key regulator of immune suppression by catalyzing the oxidation of L-tryptophan. IDO1 expression has been related to poor prognosis in several cancers and to resistance to checkpoint immunotherapies. We describe the characterization of a novel small molecule I...

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Principais autores: Yvonne Grobben, Jos de Man, Antoon M. van Doornmalen, Michelle Muller, Nicole Willemsen-Seegers, Diep Vu-Pham, Winfried R. Mulder, Martine B. W. Prinsen, Joeri de Wit, Jan Gerard Sterrenburg, Freek van Cauter, Judith E. den Ouden, Anne M. van Altena, Leon F. Massuger, Joost C. M. Uitdehaag, Rogier C. Buijsman, Guido J. R. Zaman
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-01-01
coleção:Frontiers in Immunology
Assuntos:
indoleamine 2,3-dioxygenase
cancer immunotherapy
immunosuppression
tryptophan
kynurenine
syngeneic mouse model
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2020.609490/full
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