The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production

Abstract Lysosomes are emerging as important signaling hubs for antiviral defense, yet how they enable type I interferon (IFN-β) production is unclear. Here, we identify an evolutionarily repurposed lysosomal pathway, centered on the LAMTOR-Rag GTPase complex, that governs IFN-β production through d...

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Detalhes bibliográficos

Principais autores:	Zeming Feng, Lulu Wang, Shujun Chen, Sihan Cao, Miao Lei, Xiuzhen Yang, Kaixiong Ma, Shi Yu, Huina Hu, Kaixuan Zheng, Xin Xu, Qi Zheng, Shaobo Wang, Wenxiang Hu, Chun-Yan Lim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-01-01
coleção:	The EMBO Journal
Assuntos:	Lysosomes Type I Interferon LAMTOR/Ragulator p38 MAPK Innate Immunity
Acesso em linha:	https://doi.org/10.1038/s44318-026-00695-2
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