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Rapid response to selection, competitive release and increased transmission potential of artesunate-selected Plasmodium chabaudi malaria parasites.

The evolution of drug resistance, a key challenge for our ability to treat and control infections, depends on two processes: de-novo resistance mutations, and the selection for and spread of resistant mutants within a population. Understanding the factors influencing the rates of these two processes...

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Detalles Bibliográficos
Principais autores: Laura C Pollitt, Silvie Huijben, Derek G Sim, Rahel M Salathé, Matthew J Jones, Andrew F Read
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Pathogens
Acceso en liña:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004019&type=printable
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