The β1 adrenoceptor (AR) blocker metoprolol normalises βAR cascade and caveolar protein expression and restores β1AR responsiveness in failing right ventricular myocytes

Right ventricular (RV) failure is the leading cause of death in pulmonary artery hypertension (PAH) and treatments that preserve RV contractility are urgently required. β-adrenoceptor blockers (BB) are used clinically in left ventricular failure to improve β-adrenoceptor (AR) responsiveness but it i...

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Автори:	Ruth Norman, Rachel Stones, Amelia S. Power, Ed White, Sarah C. Calaghan, Ewan D. Fowler
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2026-09-01
Серія:	Journal of Molecular and Cellular Cardiology Plus
Предмети:	Pulmonary arterial hypertension beta-adrenoceptor Caveolae beta-blocker Heart failure Right ventricle
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S2772976126000243
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