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CYP2A13 upregulation contributes to lung tumorigenesis upon NNK exposure

Lung cancer remains one of the most prevalent and deadly malignant neoplasms worldwide, with smoking being a primary risk factor. Among the numerous carcinogens in tobacco smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most potent. The carcinogenic effects of NNK are belie...

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Principais autores: Yunping Zhao, Zheng Wang, Zhihan Zhou, Donghuai Ge, Jingjing Wang, Nan Cheng, Liuxian Ye, Zhihui Pan, Liangyu Chen, Limeng Hu, Xuelei Liu, Shirui Huang, Jingxia Li, Lei Yin, Qipeng Xie, Guiying Wang, Chuanshu Huang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-07-01
coleção:Ecotoxicology and Environmental Safety
Assuntos:
NNK
CYP2A13
P-PP2A-C
TRIM25
Lung carcinogenesis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0147651326006536
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