Concomitant radiation therapy and trastuzumab deruxtecan in metastatic breast cancer: feasibility, safety, and outcomes from a real-life multicentre international cohort

Background and purpose: Radiation therapy (RT) remains a cornerstone of management for metastatic breast cancer (mBC), though systemic therapy drives overall disease control. Administering RT concomitantly with systemic treatment may raise concerns regarding toxicity. This multicentre retrospective...

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Auteurs principaux:	Luca Visani, Ivica Ratosa, Rupert Bartsch, Barbro Linderholm, Gaia Griguolo, Calogero Saieva, Carlotta Becherini, Marianna Valzano, Viola Salvestrini, Angelika M. Starzer, Peter Kus, Niccolò Bertini, Andrea Rampini, Chiara Mattioli, Domen Ribnikar, Jacopo Nori Cucchiari, Lorenzo Orzalesi, Simonetta Bianchi, Matteo Lambertini, Valentina Guarneri, Lorenzo Livi, Icro Meattini
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2026-02-01
Collection:	Breast
Sujets:	Metastatic breast cancer Trastuzumab deruxtecan Radiotherapy Concomitant therapy Adverse events Brain metastases
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0960977626000019
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