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GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VHHs, we explored the VHH scaffold in a structure-guided app...

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Hlavní autoři: Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, Ahmad Reza Mehdipour, Bram Laukens, Wim Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, Karel Thooft, Sandrine Vanmarcke, Annelies Van Hecke, Xavier Saelens, Nico Callewaert
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis Group 2023-12-01
Edice:mAbs
Témata:
Macrophage targeting
N-glycosylation
Pichia pastoris GlycoSwitchM5
Single-domain antibody scaffold
VHHs
On-line přístup:https://www.tandfonline.com/doi/10.1080/19420862.2023.2210709
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