Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

Abstract The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine and generates levodopa (l-dopa) with tetrahydrobiopterin (BH4) as a coenzyme. Here, we show that oral berberine...

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Detalhes bibliográficos

Principais autores:	Yan Wang, Qian Tong, Shu-Rong Ma, Zhen-Xiong Zhao, Li-Bin Pan, Lin Cong, Pei Han, Ran Peng, Hang Yu, Yuan Lin, Tian-Le Gao, Jia-Wen Shou, Xiao-Yang Li, Xian-Feng Zhang, Zheng-Wei Zhang, Jie Fu, Bao-Ying Wen, Jin-Bo Yu, Xuetao Cao, Jian-Dong Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2021-02-01
coleção:	Signal Transduction and Targeted Therapy
Acesso em linha:	https://doi.org/10.1038/s41392-020-00456-5
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