CelFiE-ISH: a probabilistic model for multi-cell type deconvolution from single-molecule DNA methylation haplotypes

Abstract Deconvolution methods infer quantitative cell type estimates from bulk measurement of mixed samples including blood and tissue. DNA methylation sequencing measures multiple CpGs per read, but few existing deconvolution methods leverage this within-read information. We develop CelFiE-ISH, wh...

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Bibliografske podrobnosti

Principais autores:	Irene Unterman, Dana Avrahami, Efrat Katsman, Timothy J. Triche, Benjamin Glaser, Benjamin P. Berman
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-06-01
Serija:	Genome Biology
Teme:	Bioinformatics Next-generation sequencing DNA methylation Deconvolution WGBS RRBS
Online dostop:	https://doi.org/10.1186/s13059-024-03275-x
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