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Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.

The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while enduring high amyloid plaque loads for decades. If...

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Detalhes bibliográficos
Principais autores: Chera L Maarouf, Ian D Daugs, Tyler A Kokjohn, Douglas G Walker, Jesse M Hunter, Jane C Kruchowsky, Randy Woltjer, Jeffrey Kaye, Eduardo M Castaño, Marwan N Sabbagh, Thomas G Beach, Alex E Roher
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3210154?pdf=render
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