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Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination

Summary: Termination of DNA replication occurs when two replication forks converge upon the same stretch of DNA. Resolution of topological stress by topoisomerases is crucial for fork convergence in bacteria and viruses, but it is unclear whether similar mechanisms operate during vertebrate terminat...

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Bibliografiske detaljer
Principais autores: Darren R. Heintzman, Lillian V. Campos, Jo Ann W. Byl, Neil Osheroff, James M. Dewar
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019-10-01
Serier:Cell Reports
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124719311593
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