Cysteine-reactive mitigators of small vessel disease-related NOTCH3 mutants
Abstract Pathogenic alterations in NOTCH3 cause CADASIL, an accelerated and currently untreatable form of cerebrovascular disease. CADASIL mutant NOTCH3, which frequently harbors abnormalities in EGF repeat cysteine number, adopt disulfide dependent abnormal conformations. To seek potential strategi...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Portfolio
2026-03-01
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| Colección: | Scientific Reports |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1038/s41598-026-45103-1 |
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