Validation of a predictive risk score of aggressive PK/PD target non-attainment with continuous infusion piperacillin/tazobactam or meropenem in critically ill patients having documented Gram-negative infections

Abstract Objective To validate a predictive risk score of early aggressive pharmacokinetic/pharmacodynamic (PK/PD) target non-attainment with continuous infusion (CI) piperacillin/tazobactam or meropenem in a retrospective cohort of critically ill patients having documented Gram-negative infections....

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Detalhes bibliográficos

Principais autores:	Milo Gatti, Pierantonio Grimaldi, Matteo Rinaldi, Antonio Siniscalchi, Tommaso Tonetti, Pierluigi Viale, Federico Pea
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	Journal of Anesthesia, Analgesia and Critical Care
Assuntos:	Critically ill patients Beta-lactams Early aggressive PK/PD target attainment Score validation Microbiological failure
Acesso em linha:	https://doi.org/10.1186/s44158-025-00324-0
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