Selective inhibition of BRAF and CRAF sensitizes NF1-deficient malignant peripheral nerve sheath tumors to MEK inhibitors

Abstract Background Treatment for patients with malignant peripheral nerve sheath tumors (MPNST) is an unmet clinical need. Loss of NF1 in MPNST leads to hyperactivation of RAS, however little is known about relevant downstream oncogenic signaling through RAF paralogs and effective targeted therapie...

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Detalhes bibliográficos

Principais autores:	Jiawan Wang, Arnab Sarkar, Natalia Garcia, Lindy Zhang, Ana Calizo, Alla Lisok, Katia Campos, Funan He, Nishanth Punjaala, Teresa Marple, Kai Pollard, Siyuan Zheng, Calixto-Hope G. Lucas, Vesselina G. Cooke, Christine A. Pratilas, Angelina V. Vaseva
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-09-01
coleção:	Molecular Medicine
Assuntos:	Neurofibromatosis type 1 Malignant peripheral nerve sheath tumor RAS RAF MEK
Acesso em linha:	https://doi.org/10.1186/s10020-025-01353-9
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