Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells

Abstract Brain endothelial cells experience mechanical forces in the form of blood flow-mediated shear stress and underlying matrix stiffness, but intersectional contributions of these factors towards blood–brain barrier (BBB) impairment and neurovascular dysfunction have not been extensively studie...

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Principais autores:	Alexis K. Yates, Heather Murray, Andrew Kjar, Daniel Chavarria, Haley Masters, Hyosung Kim, Alexander P. Ligocki, Angela L. Jefferson, Ethan S. Lippmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-07-01
coleção:	Fluids and Barriers of the CNS
Assuntos:	Brain microvascular endothelial cell Vascular stiffening Fluid shear stress In vitro models Inflammation
Acesso em linha:	https://doi.org/10.1186/s12987-025-00683-4
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