Circulating CD137⁺Treg cells and LOX-1⁺PMN-MDSCs as biomarkers of immunotherapy resistance in (R/M) HNSCC patients

Abstract Background Recurrent/metastatic head and neck squamous cell carcinoma ((R/M) HNSCC) represents one of the most aggressive and immunosuppressive cancers. Despite the introduction of immune checkpoint inhibitors (ICIs), only a limited number of patients obtain long-term benefits. In (R/M) HNS...

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Autores principales:	Angela Asquino, Alessio Cirillo, Lidia Strigari, Angelica Pace, Chiara Napoletano, Lucrezia Tuosto, Flavio Valentino, Andrea Ballario, Daniele Santini, Marianna Nuti, Andrea Botticelli, Aurelia Rughetti, Ilaria Grazia Zizzari
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-12-01
Colección:	Journal of Experimental & Clinical Cancer Research
Materias:	(R/M) HNSCC Anti-PD-1 immunotherapy Immune suppression CD137+ Treg cells LOX-1⁺PMN-MDSCs Blood liquid biopsy
Acceso en línea:	https://doi.org/10.1186/s13046-025-03574-6
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