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Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush

The retinal ganglion cells of the optic nerve have a limited capacity for self-repair after injury. Valproate is a histone deacetylase inhibitor and multitarget drug, which has been demonstrated to protect retinal neurons. In this study, we established rat models of optic nerve-crush injury and inje...

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Furkejuvvon:
Váldodahkkit: Feng Pan, Dan Hu, Li-Juan Sun, Qian Bai, Yu-Sheng Wang, Xu Hou
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Wolters Kluwer Medknow Publications 2023-01-01
Ráidu:Neural Regeneration Research
Fáttát:
apoptosis; c/ebp homologous protein; caspase-12; endoplasmic reticulum; glucose-regulated protein 78; optic nerve crush; phosphorylated eukaryotic translation initiation factor 2α; retinal ganglion cells; unfolded protein response; valproate
Liŋkkat:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1607;epage=1612;aulast=Pan
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