Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior

Cytotoxic immune cells are endowed with a high degree of heterogeneity in their lytic function, but how this heterogeneity is generated is still an open question. We therefore investigated if human CD8+ T cells could segregate their lytic components during telophase, using imaging flow cytometry, co...

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Detalhes bibliográficos

Principais autores:	Fanny Lafouresse, Romain Jugele, Sabina Müller, Marine Doineau, Valérie Duplan-Eche, Eric Espinosa, Marie-Pierre Puisségur, Sébastien Gadat, Salvatore Valitutti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2021-01-01
coleção:	eLife
Assuntos:	human lymphocytes cytotoxic t lymphocytes lytic granules cell division lysosomal-associated membrane proteins
Acesso em linha:	https://elifesciences.org/articles/62691
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