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Second-Generation Antipsychotics Induce Metabolic Disruption in Adipose Tissue-Derived Mesenchymal Stem Cells Through an aPKC-Dependent Pathway

Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including visceral obesity, dyslipidemia, and insulin resistance. In this regard, visceral white adipose tissue (vWAT) plays a critical role, influencing energy metabolism, immunomodulation, and oxidative stress. Adipose-derived stem...

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Principais autores: Marco Varalda, Jacopo Venetucci, Herald Nikaj, Chaitanya Reddy Kankara, Giulia Garro, Nazanin Keivan, Valentina Bettio, Paolo Marzullo, Annamaria Antona, Guido Valente, Sergio Gentilli, Daniela Capello
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-12-01
coleção:Cells
Assuntos:
second-generation antipsychotics
insulin resistance
adipose tissue
adipose-derived mesenchymal stem cells
insulin signaling
endocytosis
Acesso em linha:https://www.mdpi.com/2073-4409/13/24/2084
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