Inhibition of early EHDV2-Ibaraki infection steps in bovine cells by endosome alkalinization or ikarugamycin, but not by blockage of individual endocytic pathways

The Epizootic hemorrhagic disease virus (EHDV), an orbivirus, is the etiological factor of a fatal hemorrhagic disease of wild ruminants. A subset of EHDV serotypes, including the Ibaraki strain of EHDV2 (EHDV2-Ibaraki), infect and cause disease in cattle, thus posing a potential threat to livestock...

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Autori principali:	Maya Malka, Inbar Czaczkes, Shlomi Kashkash, Shirel Shachar, Eran Bacharach, Marcelo Ehrlich
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-02-01
Serie:	Frontiers in Cellular and Infection Microbiology
Soggetti:	EHDV2-Ibaraki clathrin-mediated endocytosis endosomes ikarugamycin entry endocytosis
Accesso online:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1494200/full
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