Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome

Abstract Background Pulmonary endothelial cells’ (ECs) injury and apoptotic death are necessary and sufficient for the pathogenesis of the acute respiratory distress syndrome (ARDS), regardless of epithelial damage. Interaction of dysfunctional ECs with circulatory extracellular vesicles (EVs) holds...

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Principais autores:	Trushil Shah, Shanshan Qin, Mona Vashi, Dan N. Predescu, Niranjan Jeganathan, Cristina Bardita, Balaji Ganesh, Salvatore diBartolo, Louis F. Fogg, Robert A. Balk, Sanda A. Predescu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2018-06-01
Series:	Clinical and Translational Medicine
Assuntos:	Acute respiratory distress syndrome Circulatory extracellular vesicles Runx1 isoforms Alk5 Endothelial cell injury
Acceso en liña:	http://link.springer.com/article/10.1186/s40169-018-0197-2
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