Metformin does not attenuate angiotensin II-induced aortic aneurysms in low-density lipoprotein receptor deficient mice

Abstract Metformin, a biguanide antihyperglycemic agent, prevents angiotensin II (AngII)-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient (ApoE-/-) mice. Low-density lipoprotein receptor-deficient (LDLR-/-) mice, a commonly used hypercholesterolemic model, closely mimics the...

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Egile Nagusiak:	Samuel C. Tyagi, Sohei Ito, Jacob C. Hubbuch, Michael K. Franklin, Deborah A. Howatt, Hong S. Lu, Alan Daugherty, Hisashi Sawada
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2025-12-01
Saila:	Scientific Reports
Gaiak:	Aorta Angiotensin Aneurysm Metformin Mouse
Sarrera elektronikoa:	https://doi.org/10.1038/s41598-025-33367-y
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