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Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells

Abstract Abstract Dapagliflozin (DAPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, is well-recognized for its therapeutic benefits in type 2 diabetes (T2D) and cardiovascular diseases. In this comprehensive in vitro study, we investigated DAPA’s effects on cardiomyocytes, aortic endothelial...

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Principais autores: Fatmah R. Alsereidi, Zenith Khashim, Hezlin Marzook, Ahmed M. Al-Rawi, Tiana Salomon, Mahra K. Almansoori, Moustafa M. Madkour, Ahmed Mohamed Hamam, Mahmoud M. Ramadan, Quinn P. Peterson, Mohamed A. Saleh
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-10-01
Serier:Cardiovascular Diabetology
Fag:
Dapagliflozin
Sodium-glucose cotransporter
Cardiomyocyte
Inflammation
AKT signaling
Endothelial cells
Online adgang:https://doi.org/10.1186/s12933-024-02481-y
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