PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation.

Rap1GAP is a GTPase-activating protein (GAP) that specifically stimulates the GTP hydrolysis of Rap1 GTPase. Although Rap1GAP is recognized as a tumor suppressor gene and downregulated in various cancers, little is known regarding the regulation of Rap1GAP ubiquitination and degradation under physio...

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Detalhes bibliográficos

Principais autores:	Dejie Wang, Pingzhao Zhang, Kun Gao, Yan Tang, Xiaofeng Jin, Yuanyuan Zhang, Qing Yi, Chenji Wang, Long Yu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-01-01
coleção:	PLoS ONE
Acesso em linha:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0110296&type=printable
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