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Proteomic and phosphoproteomic analysis of rabies pathogenesis in the clinical canine brain and identification of a kinase inhibitor as a potential repurposed antiviral agent.

Rabies is a fatal zoonosis caused by the rabies virus (RABV) that has afflicted humans for thousands of years. RABV infection leads to neurological symptoms and death; however, its pathogenesis in the brain is unclear, which complicates patient care. Given that no treatment exists for symptomatic ca...

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Autori principali: Peerut Chienwichai, Kunjimas Ketsuwan, Boonlert Lumlertdacha, Chanon Fa-Ngoen, Punchaya Supasawat, Rojjanaporn Pulmanausahakul, Promsin Masrinoul, Tipparat Thiangtrongjit, Onrapak Reamtong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2025-01-01
Serie:PLoS ONE
Accesso online:https://doi.org/10.1371/journal.pone.0323931
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