Therapeutic targeting of protein arginine methyltransferases reduces breast cancer progression by disrupting angiogenic pathways

Protein arginine methylation is an epigenetic modification involved in transcription, splicing and signal transduction and is mediated by protein arginine methyltransferases (PRMTs). PRMTs regulate various tumor angiogenesis pathways, including vascular endothelial growth factor receptor-2 (VEGFR-2)...

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Detalhes bibliográficos

Principais autores:	Kamohelo Maphalala, Dakalo Portia Ramali, Lorraine Tshegofatso Maebele, Thanyani Victor Mulaudzi, Peace Mabeta, Zodwa Dlamini, Botle Precious Damane
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
coleção:	Biochemistry and Biophysics Reports
Assuntos:	Breast cancer Angiogenesis Angiogenic signaling pathways Hypoxia Vascularization Protein arginine methyltransferase inhibitors
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405580825002596
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